1) In silico computer-aided drug design
2) Synthesis of Potentially Useful Antibiotic Compounds
3) In vitro Testing of Newly Synthesized Antibiotic Compounds
4) In vivo Testing of Newly Synthesized Antibiotic Compounds
pneumoniae pneumonia rat model of infection. Treatment with known antibiotics comparator) or the newly synthesized aaRS(s) inhibitors will be started 24h after inoculation of the left lung with K. pneumoniae bacteria, and compound administration will be carried out for 3 days. Different antibiotic formulations will be tested (depending on PK data).